Asian Journal of Research in Chemistry

N. Senthilkumar ¹, B. Jayalakshmi ¹, Joicy Jose ¹, K. Sumathi ¹

Affiliations
1 Department of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, B. Komarapalayam, Namakkal, Tamil Nadu – 638 183, IN

Abstract

The chalcone was synthesized from cyclohexanone and an aromatic aldehyde by aldol condensation reaction, followed by cyclisation with thiourea results in hexahydro quinazoline. The third position is methylated by using methyl iodide, finally the mannich reaction was carried out with five different amines at second position of the hexahydro quinazoline to get five different S-Mannich bases. All the 5 synthesized new compounds were studied for their physiochemical characters. And their structures were confirmed by spectral studies (IR, NMR). These new derivatives were evaluated for analgesic and anti-inflammatory activity.

Keywords

S-Mannich Bases, Quinazoline, Chalcone.

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V. Murugan ¹, S. Revathi ², K. Sumathi ³, K. M. Geetha ¹, Kalpana Divekar ¹

Affiliations
1 Dayanandasagar College of Pharmacy, Bangalore, Karnataka, IN
2 JSS College of Pharmacy, Ooty, Tamilnadu, IN
3 JKKMMRS College of Pharmacy, Kumarapalayam, Tamilnadu, IN

Abstract

A series of 1-[Bis-N, N-(2-Chloroethyl) aminoacetyl]-3,5-disubstituted-1,2 pyrazolines have been synthesized by the treatment of 1-[Bis-N, N-(2-hydroxyethyl) aminoacetyl]-3,5-disubstituted-1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, 1H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.

Keywords

Synthesis, Pyrazoline Derivatives, Anticancer Activity, Dalton’s Lymphoma Ascite (DLA) Cell Line.

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